Molecular characterization of HIV type 1 isolates from untreated patients of Mumbai (Bombay), India, and detection of rare resistance mutations.

نویسندگان

  • Alaka Deshpande
  • Patricia Recordon-Pinson
  • Ranjana Deshmukh
  • Muriel Faure
  • Valérie Jauvin
  • Isabelle Garrigue
  • Marie-Edith Lafon
  • Hervé J Fleury
چکیده

The molecular characterization of HIV-1 isolates in drug-naive cases in the early stages of HIV disease was studied in 128 cases from Mumbai (Bombay), India. Subtype C was largely predominant followed by A-C intersubtype recombinants, one subtype A and one CRF01 AE. Compared to subtype B, subtype C exhibited an important polymorphism; the percentages of substitutions could reach more than 90%. Two isolates showed M184V substitution the reverse transcriptase indicating resistance to 3TC.

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عنوان ژورنال:
  • AIDS research and human retroviruses

دوره 20 9  شماره 

صفحات  -

تاریخ انتشار 2004