A Conserved Hypothetical Protein Rv 0574 c Is Required for Cell Wall 1 Integrity , Stress Tolerance and Virulence of Mycobacterium 2 tuberculosis
نویسندگان
چکیده
A Conserved Hypothetical Protein Rv0574c Is Required for Cell Wall 1 Integrity, Stress Tolerance and Virulence of Mycobacterium 2 tuberculosis 3 Rajni Garg, Deeksha Tripathi , Sashi Kant , Harish Chandra, Rakesh Bhatnagar 4 Nirupama Banerjee 5 6 1. School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India. 7 2. International Centre for Genetic Engineering and Biotechnology, New Delhi 8 110067, India. 9 3. School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067. 10 € Present Address: Department of Pathology, Ohio State University College of 11 Medicine, The Ohio State University, Columbus, OH 43210, USA. 12 § Present address: Microbial Pathogenesis Laboratory, Department of 13 Environmental Health, University of Cincinnati College of Medicine, Cincinnati, 14 OH 45267, USA. 15 Authors contributed equally to the work. 16 17 Running title: Rv0574c contributes to virulence of M. tuberculosis 18 19 * Corresponding author: 20 Mailing Address: School of Biotechnology, Jawaharlal Nehru University, New Delhi 21 110067, India 22 Tel: 01126742651; Fax: 011-26742040 23
منابع مشابه
The Listeria monocytogenes PASTA Kinase PrkA and Its Substrate YvcK Are Required for Cell Wall Homeostasis, Metabolism, and Virulence
Obstacles to bacterial survival and replication in the cytosol of host cells, and the mechanisms used by bacterial pathogens to adapt to this niche are not well understood. Listeria monocytogenes is a well-studied Gram-positive foodborne pathogen that has evolved to invade and replicate within the host cell cytosol; yet the mechanisms by which it senses and responds to stress to survive in the ...
متن کاملVirulence in isoniazid-resistant clinical isolates of Mycobacterium tuberculosis from south India
Isoniazid, is the only antituberculous drug for which the relation between lack of virulence and acquisition of resistance was associated. INH-resistant mutants were shown to contain defective katG gene. Classical studies showed that INH-resistant south Indian isolates have lower virulence in guinea pigs and higher susceptibility to H2O2. It is of interest to assess the virulence in south India...
متن کاملIdentification of Mycobacterium tuberculosis adherence-mediating components: a review of key methods to confirm adhesin function
Anti-adhesion therapy represents a potentially promising avenue for the treatment and prevention of tuberculosis in a post-antibiotic era. Adhesins are surface-exposed microbial structures or molecules that enable pathogenic organisms to adhere to host surfaces, a fundamental step towards host infection. Although several Mycobacterium tuberculosis adhesins have been identified, it is predicted ...
متن کاملProtein profiling and analysis of drug sensitive and multidrug resistant isolates of Mycobacterium tuberculosis by native polyacrylamide gel electrophoresis and mass spectrometry
Introduction: Tuberculosis (TB) remains a deadly infectious disease despite all the efforts to reduce its incidence. Spread of multidrug resistant TB has seriously undermined the efforts to control the disease globally. In this study protein expression profile of MDR and sensitive isolates of MTB were analyzed and compared in order to identify proteins, which could be used in prevention, diagno...
متن کاملDifferential protein expression in Mycobacterium tuberculosis susceptible and multidrug resistant isolates
Introduction: Infections by multidrug resistant Mycobacterium tuberculosis (MDR-TB) is a major public health challenge. Secretion of proteins by M. tuberculosis plays an important role in the pathogenesis of the bacterium. We compared the protein profiles of susceptible M. tuberculosis and MDR-TB isolates using proteomic analyses, namely two dimensional gel electrophoresis (2DE) and mass spectr...
متن کامل