P53 and Thymidine Dimer Induction in Daily Low Emission Broad Band UV Treatment
ثبت نشده
چکیده
Phototherapy is a widely used treatment for multiple skin diseases, but particularly in psoriasis [1,2]. Many modalities for phototherapy have been used and investigated in the treatment of psoriasis patients: UVA with psoralens (so called local or systemic PUVA), broadband UVB (BB-UVB) and narrowband UVB (NB-UVB). These UV-treatments can be given in different schemes daily, twice or thrice weeklyand they can be used even in combination with systemic therapy, for instance to enhance the effect of retinoids, or they can be combined with local treatment (e.g. the Goeckerman regimen) [1,3,4].
منابع مشابه
p53 mutant human glioma cells are sensitive to UV-C-induced apoptosis due to impaired cyclobutane pyrimidine dimer removal.
The p53 protein is a key regulator of cell responses to DNA damage, and it has been shown that it sensitizes glioma cells to the alkylating agent temozolomide by up-regulating the extrinsic apoptotic pathway, whereas it increases the resistance to chloroethylating agents, such as ACNU and BCNU, probably by enhancing the efficiency of DNA repair. However, because these agents induce a wide varie...
متن کاملInduction of ARI12 upon broad band UV-B radiation is suppressed by UVR8 and cryptochromes
ARI12 belongs to a family of 16 potential E3 ligases in Arabidopsis and is strongly induced in leaves upon low and high fluence rates (HFR) of UV-B. We have shown that ARI12 is a downstream target of the UV-B receptor, UVR8, and the transcription factors HY5 and HYH under low fluence rates. However under HFR of broad band UV-B ARI12 expression was still downstream of HY5 and HYH but increased i...
متن کاملPhysical variables in experimental photocarcinogenesis and quantitative relationships between stages of tumor development.
Solar ultraviolet (UV) radiation is a prominent environmental carcinogen, but it does not penetrate any deeper than the skin. The UV-related skin cancers are by far the most common form of cancer among white Caucasians in the USA and Australia, and this poses a serious public health problem. Chronic UV exposure of hairless mice is a well established model for squamous cell carcinomas in man. It...
متن کاملThiothymidine plus low-dose UVA kills hyperproliferative human skin cells independently of their human papilloma virus status.
The thymidine analogue 4-thiothymidine (S(4)TdR) is a photosensitizer for UVA radiation. The UV absorbance spectrum of S(4)TdR and its incorporation into DNA suggests that it might act synergistically with nonlethal doses of UVA to selectively kill hyperproliferative or cancerous skin cells. We show here that nontoxic concentrations of S(4)TdR combine with nonlethal doses of UVA to kill prolife...
متن کاملSynthesis and Investigation of Structural, Magnetic and Antibacterial Properties of Calcium-Magnesium Ferrite Nanoparticles by Thermal Treatment Method
This paper reports optical, magnetic and antibacterial properties of calcium-magnesium nanostructure which was prepared by a simple thermal treatment method. Calcination was conducted at temperatures 500 K, The influence of calcination temperature on the degree of crystallinity, microstructure, and phase composition was investigated by different characterization techniques, i.e., X-ray diffract...
متن کامل