Uric acid secretion from mouse adipose tissue 1 Uric acid secretion from adipose tissue and its increase in obesity*
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چکیده
Uric acid is a product of metabolic breakdown of purine nucleotides. In humans, uric acid is the final oxidation product of purine catabolism (1). Elevated serum uric acid (hyperuricemia) is closely associated with visceral far accumulation (2-4) and various metabolic disorders such as glucose intolerance, elevated blood pressure, dyslipidemia and atherosclerotic cardiovascular diseases, conceptualized as the metabolic syndrome (5-10). The level of serum uric acid is determined by a balance between purine dietary uptake and production and excretion of uric acid. It is thought that uric acid is mainly produced in the liver and almost excreted through the urinary tract. However, there is little or no information about purine metabolism in various tissues, especially purine production. Our group has reported previously the presence of low uric acid clearance in obese http://www.jbc.org/cgi/doi/10.1074/jbc.M113.485094 The latest version is at JBC Papers in Press. Published on August 2, 2013 as Manuscript M113.485094
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Uric acid secretion from adipose tissue and its increase in obesity.
Obesity is often accompanied by hyperuricemia. However, purine metabolism in various tissues, especially regarding uric acid production, has not been fully elucidated. Here we report, using mouse models, that adipose tissue could produce and secrete uric acid through xanthine oxidoreductase (XOR) and that the production was enhanced in obesity. Plasma uric acid was elevated in obese mice and at...
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