PGC-1 plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle
نویسندگان
چکیده
Tuoyu Geng,* Ping Li,* Mitsuharu Okutsu, Xinhe Yin, Jyeyi Kwek, Mei Zhang, and Zhen Yan Department of Medicine, Duke University Medical Center, Durham, North Carolina; Cardiovascular and Metabolic Diseases Program, Duke-National University of Singapore (NUS) Graduate Medical School, Singapore, Singapore; and Department of Medicine-Cardiovascular Medicine, Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia
منابع مشابه
PGC-1alpha plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle.
Endurance exercise stimulates peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) expression in skeletal muscle, and forced expression of PGC-1alpha changes muscle metabolism and exercise capacity in mice. However, it is unclear if PGC-1alpha is indispensible for endurance exercise-induced metabolic and contractile adaptations in skeletal muscle. In this study, we s...
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Lira VA, Benton CR, Yan Z, Bonen A. PGC-1 regulation by exercise training and its influences on muscle function and insulin sensitivity. Am J Physiol Endocrinol Metab 299: E145–E161, 2010. First published April 6, 2010; doi:10.1152/ajpendo.00755.2009.—The peroxisome proliferator-activated receptor(PPAR ) coactivator-1 (PGC-1 ) is a major regulator of exercise-induced phenotypic adaptation and s...
متن کاملPGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity.
The peroxisome proliferator-activated receptor-gamma (PPARgamma) coactivator-1alpha (PGC-1alpha) is a major regulator of exercise-induced phenotypic adaptation and substrate utilization. We provide an overview of 1) the role of PGC-1alpha in exercise-mediated muscle adaptation and 2) the possible insulin-sensitizing role of PGC-1alpha. To these ends, the following questions are addressed. 1) Ho...
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Yan Z, Okutsu M, Akhtar YN, Lira VA. Regulation of exercise-induced fiber type transformation, mitochondrial biogenesis, and angiogenesis in skeletal muscle. J Appl Physiol 110: 264 –274, 2011. First published October 28, 2010; doi:10.1152/japplphysiol.00993.2010.—Skeletal muscle exhibits superb plasticity in response to changes in functional demands. Chronic increases of skeletal muscle contra...
متن کاملRegulation of exercise-induced fiber type transformation, mitochondrial biogenesis, and angiogenesis in skeletal muscle.
Skeletal muscle exhibits superb plasticity in response to changes in functional demands. Chronic increases of skeletal muscle contractile activity, such as endurance exercise, lead to a variety of physiological and biochemical adaptations in skeletal muscle, including mitochondrial biogenesis, angiogenesis, and fiber type transformation. These adaptive changes are the basis for the improvement ...
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