How does Trichinella spiralis make itself at home?

Secretory Products of Trichinella spiralis Muscle Larvae and Immunomodulation: Implication for Autoimmune Diseases, Allergies, and Malignancies

Trichinella spiralis has the unique ability to make itself "at home" by creating and hiding in a new type of cell in the host body that is the nurse cell. From this immunologically privileged place, the parasite orchestrates a long-lasting molecular cross talk with the host through muscle larvae excretory-secretory products (ES L1). Those products can successfully modulate parasite-specific imm...

Decreased susceptibility to Listeria monocytogenes in mice after infection with Trichinella spiralis.

Mice challenged intravenously with Listeria monocytogenes at 7 or 21 days after Trichinella spiralis infection demonstrated a higher mean lethal dose and longer survival time than normal mice. This effect of helminthic infection was abrogated after 49 days.

Analysis of a 43-kDa glycoprotein from the intracellular parasitic nematode Trichinella spiralis.

The L1 larvae of the parasitic nematode Trichinella spiralis invade skeletal muscle and initiate a process that has been interpreted to represent skeletal muscle dedifferentiation. In this process, the infected region of the muscle cell is converted into a unique structure, called the Nurse cell. The nematode T. spiralis can survive for tens of years within the cytoplasm of the Nurse cell and s...

Expressed sequence tags from life cycle stages of Trichinella spiralis: application to biology and parasite control.

While the approach taken to date to study Trichinella spp., involves mainly characterization of individual genes of interest, we initiated a genomics approach as an antecedent to more complete genome sequencing. Our approach involves use of expressed sequence tags (ESTs) obtained from three life cycle stages of Trichinella spiralis; adult worms (AD), mature muscle larvae (ML) and immature L1 la...

Experimental and immunological comparison of Trichinella spiralis and Trichinella nativa