PPAR regulates glucose metabolism and insulin sensitivity
نویسندگان
چکیده
*Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115; ‡Howard Hughes Medical Institute, Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037; Departments of §Biology and ¶Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093; Laboratory of Metabolism, Division of Basic Sciences, National Cancer Institute, Bethesda, MD 20892; **Marine Biotechnology Laboratory, School of Earth and Environmental Sciences and Center for Marine Natural Products Drug Discovery, Seoul National University, Seoul 151-747, Korea; and ††Department of Veterinary Science and Center for Molecular Toxicology and Carcinogenesis, Pennsylvania State University, University Park, PA 16802
منابع مشابه
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The transcription of many genes involved in lipid metabolism is regulated by the peroxisome proliferator– activated receptor-g (PPAR-g). The Pro12Ala polymorphism in the PPAR-g2 gene has been associated with reduced transcriptional activity in vitro and increased insulin sensitivity in vivo. Although PPAR-g has been demonstrated in human b-cells, it is unknown whether the Pro12Ala polymorphism ...
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تاریخ انتشار 2006