Immunology and Microbiology Development of a Poly-e-Lysine Contact Lens as a Drug Delivery Device for the Treatment of Fungal Keratitis
نویسندگان
چکیده
Andrew G. Gallagher, Keri McLean, Rosalind M. K. Stewart, Don A. Wellings, Heather E. Allison, and Rachel L. Williams Department of Eye and Vision Science, Institute of Ageing and Chronic Diseases, University of Liverpool, Liverpool, United Kingdom SpheriTech Ltd., Runcorn, Cheshire, United Kingdom St. Paul’s Eye Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom Department of Functional and Comparative Genomics, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom
منابع مشابه
Development of a Poly-e-Lysine Contact Lens as a Drug Delivery Device for the Treatment of Fungal Keratitis
Andrew G. Gallagher, Keri McLean, Rosalind M. K. Stewart, Don A. Wellings, Heather E. Allison, and Rachel L. Williams Department of Eye and Vision Science, Institute of Ageing and Chronic Diseases, University of Liverpool, Liverpool, United Kingdom SpheriTech Ltd., Runcorn, Cheshire, United Kingdom St. Paul’s Eye Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom Department of...
متن کاملDevelopment of a Poly-ε-Lysine Contact Lens as a Drug Delivery Device for the Treatment of Fungal Keratitis.
Purpose The purpose of this study was to develop a more efficient drug delivery device to overcome the limitations of current drop therapy for the treatment of fungal keratitis. Methods Amphotericin B (AmpB), 0 to 30 μg/mL, was associated with a poly-ε-lysine (pεK) hydrogel. Fungicidal effect against Candida albicans was assessed at 18 and 42 hours by optical density (OD600) and growth on aga...
متن کاملDetection of fungi by conventional methods and semi-nested PCR in patients with presumed fungal keratitis
Background and Purpose: Fungal keratitis is a suppurative, ulcerative, and sight-threatening infection of the cornea that sometimes leads to blindness. The aims of this study were: recuperating facilities for laboratory diagnosis, determining the causative microorganisms, and comparing conventional laboratory diagnostic tools and semi-nested PCR. Materials and Methods: Sampling was conducted in...
متن کاملSensitivity Pattern of Bacteria Isolated from Contact Lens Wearers in the Faculty of Pharmacy, Karachi University Student Population
Contact lens wearers are at great risk of developing microbial keratitis because of incorrect usages and unhygienic maintenance of contact lenses. Therefore, the present study was planned to provide data that will be helpful in selecting the anti-microbial to cure microbial keratitis. One hundred bacterial isolates from conjunctiva of contact lenses wearer were isolated, identified and subjecte...
متن کاملامکان استفاده از آنزیم EcoR1 در طبقه بندی سویه های اکانتامبای ایزوله شده از التهاب قرنیه
Acanthamoeba keratitis is increasingly being diagnosed among people who wear thrapeutic and cosmetic contact lenses. The chain of events is thought to begin with contamination of the contact lens storage cases with Acanthamoeba from household or mains water supplies. If bacteria contamination is also present then these amoebas can multiply by ingesting the bacteria as a food source. If the cont...
متن کامل