Organized nerve tissue cultures infected with Mycobacterium leprae and Mycobacterium lepraemurium.
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چکیده
منابع مشابه
Ocular histopathology in animals experimentally infected with Mycobacterium leprae and M. lepraemurium 1. Mycobacterium leprae and M. Iepraemurium infections in the mouse
At varying periods of time following the successful establishment of systemic infections with Mycobacterium leprae or M. lepraemurium in the mouse and the nine-banded armadillo eyes were examined by light microscopy. Inoculation of bacilli was by the intravenous or intraperitoneal route or directly into the hind footpads; eyes were not directly inoculated in this study. During periods of up to ...
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Organized nerve cultures of dorsal root ganglia from neonatal mice were infected with Mycobacterium leprae, the causative agent of leprosy. A significant multiplication of the acid-fast bacilli was observed within the Schwann cell component of the culture. The growth of these bacilli was sensitive to antileprosy drugs and was not observed directly in bacteriological media. These organisms were ...
متن کاملIn vitro cultivation of mycobacteria from human lepromas and from an armadillo infected with mycobacterium leprae.
Experimental evidence has been presented that the host-grown, hitherto noncultivated mycobacteria, M. leprae and M. lepraemurium are metabolically competent microorganisms (1. 5.6. X. II . 12. 14). They are provided with a complete and functional tricarboxylic acid cycle and electron transport chain. We also described ( 5.6. 10. II . JJ) that M . leprae and M. lepraemurium have the capacity to ...
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Mycobacterium marinum is a photochromogenic myco bacterium capable of indu c in g a se lflimitin g loca li zed infection within the mouse foot pad ( 1.4 ). Because this infection is íwalogous to the M. leprae infection in the mouse, it has been suggested as an a lternative experimenta l model for studying the role of host immunity to M. leprae infection in the mouse foot pad (1 2. 16. 19). Pres...
متن کاملLimited in vitro multiplication of Mycobacterium leprae: application to screening potential antileprosy compounds.
Inability to cultivate Mycobacterium leprae in vitro has been regarded as the bottleneck which obstructs research on modes of transmission, pathogenesis, immunization and the treatment of leprosy . The bottleneck in the cultivation problem always has been that of gaining significant information from an organism that has given no useful response to intensive inquiries by the disciplines of bioch...
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ورودعنوان ژورنال:
- International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
دوره 42 2 شماره
صفحات -
تاریخ انتشار 1974