Synergistic effect of nitrilotriacetate on iron mobilization by desferrioxamine in vivo.
نویسندگان
چکیده
Removal of iron from biologically important ligands by desferrioxamine (DF), in vitro, is exceedingly slow because of a kinetic barrier. This kinetic barrier can be overcome by a variety of a small molecular weight anions, of which nitrilotriacetate (NTA) is a prototype. We explored the effect of NTA on DF iron mobilization in vivo. Iron mobilization was increased and the effect was synergistic.
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ورودعنوان ژورنال:
- Blood
دوره 57 6 شماره
صفحات -
تاریخ انتشار 1981