Rare Coding Variation and Risk of Intracerebral Hemorrhage.
نویسندگان
چکیده
BACKGROUND AND PURPOSE Intracerebral hemorrhage has a substantial genetic component. We performed a preliminary search for rare coding variants associated with intracerebral hemorrhage. METHODS A total of 757 cases and 795 controls were genotyped using the Illumina HumanExome Beadchip (Illumina, Inc, San Diego, CA). Meta-analyses of single-variant and gene-based association were computed. RESULTS No rare coding variants were associated with intracerebral hemorrhage. Three common variants on chromosome 19q13 at an established susceptibility locus, encompassing TOMM40, APOE, and APOC1, met genome-wide significance (P<5e-08). After adjusting for the APOE epsilon alleles, this locus was no longer convincingly associated with intracerebral hemorrhage. No gene reached genome-wide significance level in gene-based association testing. CONCLUSIONS Although no coding variants of large effect were detected, this study further underscores a major challenge for the study of genetic susceptibility loci; large sample sizes are required for sufficient power except for loci with large effects.
منابع مشابه
A case report of nephrotic syndrome with hemorrhage of intracerebral in cerebral venous thrombosis
Introduction: cerebral vein thrombosis is a rare complication of nephrotic syndrome (NS).We report a known case of NS with hemorrhagic thrombosis. Case report: A boy with previous history of NS was admitted with headache and decrease of level of consciousness and his brain images were revealed hemorrhagic thrombosis Conclusions: cerebral vein thrombosis must be considered in patients with...
متن کاملA study of the factors associated with non-traumatic intracerebral hemorrhage (ICH) in patients with chronic systemic hypertension
Objective: Intracerebral hemorrhage (ICH) following systemic and chronic hypertension is one of the main causes of acute stroke leading to disability and death. Identifying the risk factors in ICH patients can be effective in reducing bleeding and the rates of mortality and disability in these patients. This study was carried out to investigate the factors associated with ICH.Methods: A t...
متن کاملAssociation between Intracerebral Hemorrhage and Cerebral Palsy in Preterm Infant: A Systematic Review Article
Background: Intracerebral hemorrhage (ICH) is a type of intracranial bleed that occurs within the brain tissue or ventricles. The present study aimed to review the association between ICH and cerebral palsy (CP) in the preterm infants. Materials and Methods: <s...
متن کاملA diagnostic approach to multiple simultaneous intracerebral hemorrhages.
Multiple simultaneous intracerebral hemorrhages are rare and varied in etiology. In the absence of known risk factors or obvious underlying disease, determining the cause may be problematic. We outline a diagnostic approach to multiple simultaneous intracerebral hemorrhages in the context of three case studies. We conclude that when there are no apparent risk factors, neuroimaging and identific...
متن کاملIntracerebral and Intraventricular hemorrhage with covid-19: A case report
Background and Importance: Coronavirus 19 is caused by the SARS-COV-2 virus. The primary target of the virus is the respiratory system, but it can also affect other systems of the body, such as the cardiovascular system and the Central Nervous System )CNS). Case Presentation: In this study, we introduce an 83-year-old man who referred due to reduced level of consciousness and hemiparesis ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Stroke
دوره 46 8 شماره
صفحات -
تاریخ انتشار 2015