Antigen presenting epithelial cells play a pivotal role in airway allergy
نویسندگان
چکیده
Results Human nasal epithelial cells were shown to take up dextran, which ended up in intracellular endosome-like structures. In addition, MHC class II and co-stimulatory molecules were found on human and mouse nasal epithelial cells. Functionally, nasal epithelial cells from ovalbumin-sensitized mice activated and induced antigen-specific proliferation of naïve OT-II CD4+ T cells in vitro. A similar activation was not seen in naïve MNECs. Finally, nasal epithelial cells from allergic rhinitis patients were able to activate autologous T cells against Bet v 1 and induce IL-13 release.
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Inhibition of T cell costimulation abrogates airway hyperresponsiveness in a murine model.
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