The Origin of Nanotoxicity: Physical Damage
نویسندگان
چکیده
Now safety concern of in vivo nano-carriers toxicity is apparently hindering the extensive applications of nanotechnology in medical sciences. Many studies on the effects of nanomaterials in vitro and in vivo have been published, and revealed that nanomaterials including carbon nanotubes, fullerenes, quantum dots (for example CdS) and oxide nanoparticles (NPs) (for example ZnO, CuO and TiO2) exhibited various toxic effects on biological system. More importantly, they can cause lung inflammation, liver injury, kidney failure, or even fatality [1]. Compared with non-biodegradable nanomaterials, the same nano sized drug carriers prepared by biodegradable ones, such as albumin (Abraxane®) and phosphatides (Doxil®) used in human being approved by FDA, are fairly safe [2-4].
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