Isotretinoin (Accutane) as a Teratogen
نویسندگان
چکیده
Isotretinoin is a molecule and a byproduct (metabolite) of vitamin A, and in greater than normal amounts in pregnant women, it can cause fetal abnormalities including cleft lips, ear and eye defects, and mental retardation [5]. Isotretinoin is commonly called by its trade name Accutane, and it's a chemical compound derived from vitamin A, also called retinoic acid. Doctors prescribe isotretinoin to treat severe acne. For pregnant women, too much vitamin A or isotretinoin can also cause greater than normal rates of stillbirths and fetal disintegrations after the ninth week of gestation [6]. Women who use isotretinoin during the first trimester [7] of their pregnancies, even in small amounts, risk defects to their fetuses such as external ear malformations, cleft palates, undersized jaws (micrognathia), a variety of heart defects, buildups of fluids inside the skulls that leads to brain swelling (hydrocephalus [8]), small heads and brains (microcephaly [9]), and mental retardation [5].
منابع مشابه
Use of isotretinoin (Accutane) in the United States: rapid increase from 1992 through 2000.
BACKGROUND Isotretinoin, a drug approved to treat severe recalcitrant nodular acne, has been marketed in the United States since 1982. The drug is an effective treatment for acne that is refractory to other therapies, but it is a teratogen and can cause serious side effects. OBJECTIVE Our purpose was to describe trends in the use of isotretinoin in the United States from marketing through yea...
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Accutane “NF” is a new formulation of isotretinoin, a drug substance that was approved in 1982. The indication remains severe recalcitrant nodular acne. The Sponsor’s stated reason for pursuing this new formulation is that improved bioavailability will allow once daily dosing with or without food, as opposed to twice daily with food as per labeling for the current Accutane® formulation. The Spo...
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Subacromial septic bursitis after corticosteroid injection is exceedingly rare. This report describes a case of Staphylococcus aureus subacromial septic bursitis after corticosteroid injection in a patient undergoing isotretinoin (Accutane) therapy. This case is only the third reported in the literature linking a corticosteroid injection with septic subacromial bursitis and the first to describ...
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