Insulin Effects on Cardiac Na/ca Exchanger Activity: Role of the Cytoplasmic Regulatory Loop
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1 INSULIN EFFECTS ON CARDIAC NA/CA EXCHANGER ACTIVITY: ROLE OF THE CYTOPLASMIC REGULATORY LOOP María Celeste Villa-Abrille, Agnieszka Sidor, and Brian O’Rourke From Division of Cardiology, Department of Medicine, The Johns Hopkins University, Baltimore, MD 21205 Running head: Insulin regulation of Na/Ca exchange Address correspondence to: Brian O'Rourke, Ph.D. The Johns Hopkins University, Department of Medicine, 720 Rutland Ave., 1059 Ross Bldg., Baltimore, MD 21205-2195; E-mail: [email protected]
منابع مشابه
Insulin effects on cardiac Na+/Ca2+ exchanger activity: role of the cytoplasmic regulatory loop.
Insulin can alter myocardial contractility, in part through an effect on the cardiac sarcolemmal Na(+)/Ca(2+) exchanger (NCX), but little is known about its mechanism of action. The large cytoplasmic domain (f-loop) of NCX is required for regulation by various intracellular factors, and we have shown previously that residues 562-679 are determinants of NCX inhibition by exchanger inhibitory pep...
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