Angiotensin II-induced skeletal muscle insulin resistance mediated by NF- B activation via NADPH oxidase
نویسندگان
چکیده
Yongzhong Wei, James R. Sowers, Suzanne E. Clark, Wenhan Li, Carlos M. Ferrario, and Craig S. Stump Department of Internal Medicine, University of Missouri-Columbia; Harry S. Truman Memorial Veterans Affairs Medical Center, Columbia, Missouri; Wake Forest University School of Medicine, Winston-Salem, North Carolina; Diabetes Research Program, Department of Medicine, University of Arizona; and Southern Arizona Veterans Affairs Health Care System, Tucson, Arizona
منابع مشابه
Angiotensin II-induced skeletal muscle insulin resistance mediated by NF-kappaB activation via NADPH oxidase.
Reduced insulin sensitivity is a key factor in the pathogenesis of type 2 diabetes and hypertension. Skeletal muscle insulin resistance is particularly important for its major role in insulin-mediated glucose disposal. Angiotensin II (ANG II) is integral in regulating blood pressure and plays a role in the pathogenesis of hypertension. In addition, we have documented that ANG II-induced skeleta...
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The renin-angiotensin system (RAS) and reactive oxygen species (ROS) have been implicated in the development of insulin resistance and its related complications. There is also evidence that angiotensin II (Ang II)-induced generation of ROS contributes to the development of insulin resistance in skeletal muscle, although the precise mechanisms remain unknown. In the present study, we found that ...
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The reduced capacity of insulin to stimulate glucose transport into skeletal muscle, termed insulin resistance, is a primary defect leading to the development of prediabetes and overt type 2 diabetes. Although the etiology of this skeletal muscle insulin resistance is multifactorial, there is accumulating evidence that one contributor is overactivity of the renin-angiotensin system (RAS). Angio...
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