The Intrinsic Fragility of DNA
نویسندگان
چکیده
منابع مشابه
Chromosome fragility and the abnormal replication of the FMR1 locus in fragile X syndrome.
Fragile X Syndrome (FXS) is a learning disability seen in individuals who have >200 CGG•CCG repeats in the 5' untranslated region of the X-linked FMR1 gene. Such alleles are associated with a fragile site, FRAXA, a gap or constriction in the chromosome that is coincident with the repeat and is induced by folate stress or thymidylate synthase inhibitors like fluorodeoxyuridine (FdU). The molecul...
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