Anti-hepatitis C virus effect of citrus unshiu peel and its active ingredient nobiletin.
نویسندگان
چکیده
We investigated the effects of water and ethyl acetate extracts of Citrus unshiu peel (Aurantii Nobilis pericarpium) on hepatitis C virus (HCV) absorption in MOLT-4 cells (a human lymphoblastoid leukemia cell line). By reverse transcription polymerase chain reaction (RT-PCR), we showed that both the ethyl acetate layer of Citrus unshiu peel extract and fraction 7 decreased HCV absorption in MOLT-4 cells. Furthermore, we demonstrated that 3',4',5,6,7,8-hexamethoxyflavone (nobiletin) is the active ingredient that markedly inhibited HCV infection in MOLT-4 cells.
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ورودعنوان ژورنال:
- The American journal of Chinese medicine
دوره 33 1 شماره
صفحات -
تاریخ انتشار 2005