5-aza-2'-deoxycytidine Activates Iron Uptake and Heme Biosynthesis by Increasing C-myc Nuclear Localization and Binding to the E-boxes of Tfr1 and Ferrochelatase Genes

From CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology 1 , No.11 Zhongguancun Beiyitiao, Beijing 100190, China; The First Affiliated Hospital of Jilin University 2 , Changchun, Jilin Province 130021, China; Iron Metabolism Laboratory, Queensland Institute of Medical Research 3 , Brisbane, Queensland 4092, Australia; Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University 4 , Shijiazhuang, Hebei Province 050016, China; Department of Gastroenterology & Hepatology, Chinese PLA General Hospital 5 , Beijing 100853 China; Department of Chemical Biology and Applied Chemistry, College of Chemistry and Molecular Engineering, Peking University 6 , Beijing 100190, China; Graduate University of Chinese Academy of Sciences 7 , Beijing 100049, China †These authors contributed equally. Running head: 5-aza-CdR stimulates heme synthesis by c-Myc Address correspondence to: Guangjun Nie. Ph.D, No.11 Zhongguancun Beiyitiao, 100190 Beijing, China, Tel: 86-10-82545529 Fax: 86-10-62656765, Email: [email protected]