Murine L1210 and P388 Leukemias
نویسندگان
چکیده
Mouse leukemia models were a central component of the initial drug discovery programs employed by the Division of Cancer Treatment (DCT) of the National Cancer Institute (NCI) during the early 1960s and 1970s. The L1210 and P388 leukemias, developed in 1948 (1) and 1955 (2), respectively, played a major role in both screening and detailed evaluations of candidate anticancer agents. Today, 40 yr later, these models are still used to evaluate anticancer activity, although at a greatly reduced level, and to study mechanisms of drug resistance. This chapter reviews their past contributions, updates their present role in the evaluation of anticancer drugs, and summarizes data for the drug sensitivity of these two leukemias and various drug-resistant P388 sublines to clinically useful drugs.
منابع مشابه
Dynemicins, new antibiotics with the 1,5-diyn-3-ene and anthraquinone subunit. II. Antitumor activity of dynemicin A and its triacetyl derivative.
Dynemicin A showed extremely potent in vitro cytotoxicity against a variety of murine and human tumor cells. In the experimental animal tumor models implanted ip with P388, L1210 leukemias and B16 melanoma cells, dynemicin A administered ip significantly prolonged life-span of tumor-bearing mice with the wide range of activity. This antibiotic administered iv was also active against iv implante...
متن کاملAntitumor activity of macromomycin B (NSC 170105) against murine leukemias, melanoma, and lung carcinoma.
Mice bearing either of the two rapidly growing mouse leukemias, L1210 or P388, or the slow-growing B16 melanoma responded to i.p. injections of Macromomycin B (NSC 170105) with significant increases in life-span. The maximal increases in life-span obtained in these experiments were 37% for L1210, 68% for P388, and 120% for B16. In addition, there were 7 of 30 cures for varying doses of Macromom...
متن کاملEffect of Lithium on the Myelosuppressive and Chemotherapeutic Activities of Vinblastine1
Serum concentrations of lithium after i.p. administration to normal mice declined with biphasic kinetics. Treatment of mice bearing ascitic L1210 leukemia with lithium resulted in a mod est protection against the myelosuppressive effects of vinblastine. Lithium as a single agent was without effect on the survival times of mice bearing either the L1210 or P388 leukemia. Similarly, there was no e...
متن کاملEffect of lithium on the myelosuppressive and chemotherapeutic activities of vinblastine.
Serum concentrations of lithium after i.p. administration to normal mice declined with biphasic kinetics. Treatment of mice bearing ascitic L1210 leukemia with lithium resulted in a modest protection against the myelosuppressive effects of vinblastine. Lithium as a single agent was without effect on the survival times of mice bearing either the L1210 or P388 leukemia. Similarly, there was no ev...
متن کاملThe NCI In Vitro Anticancer Drug Discovery Screen
Since 1955, the US National Cancer Institute (NCI) has provided screening support to cancer researchers worldwide. Until 1985, the NCI screening program and the selection of compounds for further preclinical and clinical development under NCI auspices had relied predominantly on the in vivo L1210 and P388 murine leukemias and certain other transplantable tumor models (1). From 1975-1985, the in...
متن کامل