Blockage of angiotensin II type 1 receptor regulates TNF- -induced MAdCAM-1 expression via inhibition of NF- B translocation to the nucleus and ameliorates colitis
نویسندگان
چکیده
Takashi Mizushima, Makoto Sasaki, Tomoaki Ando, Tsuneya Wada, Mamoru Tanaka, Yasuyuki Okamoto, Masahide Ebi, Yosikazu Hirata, Kenji Murakami, Tsutomu Mizoshita, Takaya Shimura, Eiji Kubota, Naotaka Ogasawara, Satoshi Tanida, Hiromi Kataoka, Takeshi Kamiya, J. S. Alexander, and Takashi Joh Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya; and Department of Gastroenterology, Aichi Medical University School of Medicine, Aichi, Japan; and Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana
منابع مشابه
Regulation and distribution of MAdCAM-1 in endothelial cells in vitro.
Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) is a 60-kDa endothelial cell adhesion glycoprotein that regulates lymphocyte trafficking to Peyer's patches and lymph nodes. Although it is widely agreed that MAdCAM-1 induction is involved in chronic gut inflammation, few studies have investigated regulation of MAdCAM-1 expression. We used two endothelial lines [bEND.3 (brain) and SVEC (hig...
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N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a naturally occurring tetrapeptide that prevents inflammation and fibrosis in hypertension and other cardiovascular diseases. We previously showed that, in angiotensin II-induced hypertension, Ac-SDKP decreased the activation of nuclear transcription factor NF-κB, whereas, in experimental autoimmune myocarditis and hypertension animal models, i...
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BACKGROUND Endothelial MAdCAM-1 (mucosal addressin cell adhesion molecule-1) expression is associated with the oxidant-dependent induction and progress of inflammatory bowel disease (IBD). Melatonin, a relatively safe, potent antioxidant, has shown efficacy in several chronic injury models may limit MAdCAM-1 expression and therefore have a therapeutic use in IBD. METHODS We examined how diffe...
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Background: Hypertension during pregnancy period along with the presence of protein in the urine, after the 20th weeks of gestation is called preeclampsia (PE). About five percent of all pregnancies are manifested with PE and its exact etiology has still remained unknown. The renin-angiotensin system (RAS) has an important role in the regulation of blood pressure during pregnancy and so pathoph...
متن کاملAngiotensin II-induced skeletal muscle insulin resistance mediated by NF-kappaB activation via NADPH oxidase.
Reduced insulin sensitivity is a key factor in the pathogenesis of type 2 diabetes and hypertension. Skeletal muscle insulin resistance is particularly important for its major role in insulin-mediated glucose disposal. Angiotensin II (ANG II) is integral in regulating blood pressure and plays a role in the pathogenesis of hypertension. In addition, we have documented that ANG II-induced skeleta...
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