Oral Alitretinoin for the Treatment of Recalcitrant Pityriasis Rubra Pilaris
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چکیده
Treatment of pityriasis rubra pilaris is still challenging. We here present a 74-year-old woman who had not experienced stable remission of her skin symptoms during prior treatments including topical and systemic corticosteroids, phototherapy, orally administered acitretin, cyclosporine, methotrexate and adalimumab. A therapy with oral alitretinoin was started and tolerated very well. After a few weeks, skin condition improved significantly and itching and scaling disappeared. The present case shows that alitretinoin might be an alternative in the treatment of recalcitrant pityriasis rubra pilaris type I. Further studies are needed to investigate the benefit of this encouraging result.
منابع مشابه
Hand eczema and other inflammatory skin diseases: efficacy of oral alitretinoin
Background Alitretinoin is a vitamin A derivative. It’s a pan-agonist of Retinoic Acid Receptors and Retinoid X Receptors. It interferes with keratinocytes’ proliferation and differentiation and exerts immunomodulatory and anti-inflammatory activity. Its clinical efficacy in the treatment of chronic hand eczema is well demonstrated. Recently, various case reports and case series pointed out its...
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388 Ann Dermatol Received February 26, 2015, Revised May 26, 2015, Accepted for publication May 29, 2015 Corresponding author: Eun-So Lee, Department of Dermatology, Ajou University School of Medicine, 164 WorldCup-ro, Yeongtong-gu, Suwon 16499, Korea. Tel: 82-31-219-5190, Fax: 82-31-219-5189, E-mail: esl@ ajou.ac.kr This is an Open Access article distributed under the terms of the Creative Com...
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