Detecting progression of Alzheimer’s disease pathology in the triple transgenic mouse brain using 1H MRS
نویسندگان
چکیده
J. Kim, S-P. Lee, M. L. Michaelis, and I-Y. Choi Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States, Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, United States, Department of Pharmacology and Toxocology, University of Kansas, Lawrence, KS, United States, Department of Neurology, Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, United States
منابع مشابه
In vivo localized two dimensional MR spectroscopy to compare the neurochemical profile in wild-type and transgenic mouse model of Alzheimer’s disease
Introduction Currently a definitive diagnosis of Alzheimer’s disease (AD) is only possible postmortem, by detecting the two hallmarks of the disease: amyloid plaques and neurofibrillary tangles in the brain tissue. There is thus a great need for in vivo biomarkers to diagnose AD with high specificity and sensitivity. Proton magnetic resonance spectroscopy (H MRS) provides a non-invasive way to ...
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