Cell encapsulation and oxygenation in nanoporous microcontainers.

A nanoporous, transparent microcontainer for encapsulated islet therapy.

Present-day islet encapsulation techniques such as polymer microcapsules and microelectromechanical system (MEMS)-based biocapsules have shown promise in insulin replacement therapy, but they each have limitations-the permeability characteristics of existing polymeric capsules cannot be strictly controlled because of tortuosity and the large size of present-day MEMS biocapsules leads to necroti...

A Bio-artificial Pancreas Created Using Cell Encapsulation in Self-assembled Microcontainers on Alginate Sheet

ABSTRACT This paper presents a bio-artificial pancreas fabricated with self-assembled, precisely structured 3D microcontainers on a rolled-up alginate sheet. We utilize a novel 3D membrane approach developed in our laboratory to package pancreatic βcells so that they can be transplanted and function like an autonomous insulin-producing organ. Our approach provides stable and adequate diffusion ...

SU-8-based immunoisolative microcontainer with nanoslots defined by nanoimprint lithography.

Cells can secrete biotherapeutic molecules that can replace or restore host function. The transplantation of such cells is a promising therapeutic modality for the treatment of several diseases including type 1 diabetes mellitus. These cellular grafts are encapsulated in semipermeable and immunoisolative membranes to protect them from the host immune system, while allowing the transport of nutr...

Sacrificial template-directed fabrication of superparamagnetic polymer microcontainers for pH-activated controlled release of Daunorubicin.

Magnetic pH-sensitive microcontainers were produced by a four-step process. The first step involves the synthesis of citrate-modified magnetic nanoparticles via the coprecipitation method. The second step consists of the encapsulation of magnetic nanoparticles in non-cross-linked poly(methacrylic acid) (PMAA) microspheres through distillation precipitation polymerization, resulting in a core/sh...

Nanoporous hosts for the encapsulation of conductive nanostructured materials