6-(substituted methylene)penems, potent broad spectrum inhibitors of bacterial beta-lactamase. III. Structure-activity relationships of the 5-membered heterocyclic derivatives.

نویسندگان

  • I Bennett
  • N J Broom
  • G Bruton
  • S Calvert
  • B P Clarke
  • K Coleman
  • R Edmondson
  • P Edwards
  • D Jones
  • N F Osborne
چکیده

Sodium (5RS)-Z-6-(heterocyclylmethylene)penem-3-carboxylates (2) are a series of extremely potent inhibitors of bacterial beta-lactamases. A variety of 5-membered heteroaromatic derivatives have been prepared and structure-activity studies reveal a preferred substituent orientation. One of these derivatives, the 1-methyl-1,2,3-triazolyl compound (5m) is a more potent synergist of amoxycillin than clavulanic acid, sulbactam or tazobactam.

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عنوان ژورنال:
  • The Journal of antibiotics

دوره 44 3  شماره 

صفحات  -

تاریخ انتشار 1991