A New Monoclonal Antibody (CH-F42) Recognizes a CD7- Subset of Normal T Lymphocytes and Circulating Malignant Cells in Adult T-cell Lymphoma-Leukemia and SCzary Syndrome
نویسنده
چکیده
We describe a new rat immunoglobulin M monoclonal antibody (CH-F42) that recognizes a subset (1.5% to 8%) of normal peripheral blood T lymphocytes. The phenotype of these cells was determined, using dual-color immunofluorescence, to be CD2+, CD3'. CD4'. CD5'. CD7-, CD8-. They do not express T-cell activation markers, and are positive for UCHLl (CD46RO). but negative for 2H4 (CD45RA). The antigen was expressed on circulating malignant cells in Shzary syndrome (four of four cases) and adult T-cell lymphoma-leukemia (ATLL) (four of six cases) and negative in a variety of other hematologic malignancies tested. These included chronic and acute lymphoid leuke-
منابع مشابه
A new monoclonal antibody (CH-F42) recognizes a CD7- subset of normal T lymphocytes and circulating malignant cells in adult T-cell lymphoma-leukemia and Sézary syndrome.
We describe a new rat immunoglobulin M monoclonal antibody (CH-F42) that recognizes a subset (1.5% to 8%) of normal peripheral blood T lymphocytes. The phenotype of these cells was determined, using dual-color immunofluorescence, to be CD2+, CD3+, CD4+, CD5+, CD7-, CD8-. They do not express T-cell activation markers, and are positive for UCHL1 (CD45RO), but negative for 2H4 (CD45RA). The antige...
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