Obstructive Uropathy Caused by Severe Interstisial Cystitis: a Report of Two Cases

Background: Interstitial cystitis is a chronic clinical condition affecting women predominantly. Characterized by irritative voiding symptoms and suprapubic pain. Most of Interstitial cystitis cases run a benign course and the bothersome symptoms are the main concern of the treating doctors; however obstructive uropathy as a complication could occur and mostly noticed in Interstitial cystitis cases associated with connective tissue diseases in particular systemic lupus erythematosus. A variety of medical therapies used for the treatment interstitial cystitis, on the other hand, surgical management, if any, commonly indicated for intractable symptoms rather than obstructive uropathy. Aim: The aim of the present work was to discusse 2 cases of severe interstitial cystitis reported presented to the outpatient clinic. Cases: Two cases of women with severe interstitial cystitis without associated connective tissue diseases, complicated by bladder wall thickening and obstructive uropathy were reported. Results: Cases were managed successfully with oral sodium Pentosan Polysulfate (Elmiron) without the Need for invasive measures in one case and required invasive procedure in the other.