Lipids and Lipoproteins and Risk of Different Vascular Events in the MRC/BHF Heart Protection Study

Vascular Medicine Lipids and Lipoproteins and Risk of Different Vascular Events in the MRC/BHF Heart Protection Study

Letter by Kuller and Mackey regarding article, "Lipids and lipoproteins and risk of different vascular events in the MRC/BHF Heart Protection study".

BACKGROUND Low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol are established risk factors for vascular disease, but lipoprotein particle concentrations may be stronger determinants of risk. METHODS AND RESULTS Associations between vascular events and baseline concentrations of cholesterol fractions, apolipoproteins B and A(1), and lipoprotein particles a...

MRC/BHF Heart Protection Study of cholesterol-lowering therapy and of antioxidant vitamin supplementation in a wide range of patients at increased risk of coronary heart disease death: early safety and efficacy experience

Aims In observational studies, prolonged lower blood total cholesterol levels — down at least to 3 mmol . l 1 — are associated with lower risks of coronary heart disease. Cholesterol-lowering therapy may, therefore, be worthwhile for individuals at high risk of coronary heart disease events irrespective of their presenting cholesterol levels. Observational studies also suggest that increased di...

Lack of association of KIF6 genotype with vascular disease and statin response.

1. Hopewell JC, Parish S, Clarke R, Armitage J, Bowman L, Hager J, Lathrop M, Collins R; MRC/BHF Heart Protection Study Collaborative Group. No impact of KIF6 genotype on vascular risk and statin response among 18,348 randomized patients in the Heart Protection Study. J Am Coll Cardiol. 2011;57:2000–2007. 2. Ridker PM, Macfadyen JG, Glynn RJ, Chasman DI. Kinesin-like protein 6 (KIF6) polymorphi...

Comparison of Lipids and Lipoprotein Levels of Cord Blood in Neonates in Ahwaz City with the Same Parameters in Nelson Textbook of Pediatrics

Adult cardiovascular disease has its roots in childhood, Various surveys have shown a significant correlation between early atherosclerotic changes indentified at autopsy of children and young adults, and both total cholesterol (TC) and low-density lipoprotein (LDL cholesterol) levels. The hypercholesterolemic neonates time for diagnosis of high risk neonate infants. The aim of this study is to...