PS60. Associations between Pro-inflammatory cytokines and grey matter/ cortical thickness in patients with bipolar disorder

Background: Disturbances in thought, speech, and linguistic processing are frequently observed in bipolar manic patients, but the underlying neurophysiological mechanisms are not well understood. P600 is a distinct, positive event-related potential component elicited by syntactic violations. Using the P600 ERP, we examined neural processing of syntactic language comprehension in patients with bipolar mania compared to patients with schizophrenia and healthy people. Method: P600s were recorded from 21 manic patients with bipolar disorder, 26 patients with schizophrenia, and 29 healthy subjects during the presentation of 120 sentences with syntactic violations or non-violations. Subjects were asked to judge whether each sentence was correct or incorrect. Results: Patients with mania and schizophrenia had significantly smaller P600 amplitudes associated with syntactic violations compared with healthy subjects. There was no difference in P600 amplitude between patient groups. For behavioral performance, patients with schizophrenia were significantly less accurate compared with healthy subjects, whereas manic patients were not significantly different from healthy subjects. Conclusion: Despite having normal behavioral judgment of syntax, patients with bipolar mania have reduced P600 amplitude, comparable to patients with schizophrenia. Our findings may represent the first neurophysiological evidence of abnormal syntactic linguistic processing in bipolar mania. PS58 Time perception with auditory stimulus and manic symptoms in bipolar patients Chung-Su Jung, MD1, Inki Sohn, MD, PhD1, Woong Hahm, MD, PhD1, Jeoung-Seok Seo, MD, PhD2. 1Keyo Medical Foundation Keyo Hospital, Uiwang, Korea 2Department of Psychiatry, Konkun University Hospital, Seoul, Korea Abstract Objectives: The purpose of this study was to investigate 1) whether there would be significant changes in time perception between acute manic and euthymic states and 2) whether changes in time perception with auditory stimulus in bipolar patients would be consistent with changes in time perception with visual stimulus. Methods: The thirty-eight patients who were diagnosed as manic episode of bipolar disorder by DSM-IV participated in this study. They were presented with a time reproduction task at two states – acute manic state and euthymic state. Participants were asked to listen for “beep” sound on a portable sound equipment for a certain length of time. After that, they were asked to reproduce the same length of time. The psychopathology was measured using Young Mania Rating Scale (YMRS) and Hamilton Depression Rating Scale(HDRS) by a trained psychologist. After 6 weeks of drug treatment, the psychopathology were retested by the same psychologist. Results: Time reproduction for 11 seconds, 36 seconds in acute manic state were shorter than in euthymic state and time reproduction in acute manic state were correlated with YMRS score. Conclusions: Time reproduction is shorter in acute manic state than in euthymic state. And the severity of manic symptom is correlated with time perception. This result is consistent with previous studies with visual stimulus and suggests that the difference between cognitive process of visual stimulus and auditory stimulus does not affect time perception.Objectives: The purpose of this study was to investigate 1) whether there would be significant changes in time perception between acute manic and euthymic states and 2) whether changes in time perception with auditory stimulus in bipolar patients would be consistent with changes in time perception with visual stimulus. Methods: The thirty-eight patients who were diagnosed as manic episode of bipolar disorder by DSM-IV participated in this study. They were presented with a time reproduction task at two states – acute manic state and euthymic state. Participants were asked to listen for “beep” sound on a portable sound equipment for a certain length of time. After that, they were asked to reproduce the same length of time. The psychopathology was measured using Young Mania Rating Scale (YMRS) and Hamilton Depression Rating Scale(HDRS) by a trained psychologist. After 6 weeks of drug treatment, the psychopathology were retested by the same psychologist. Results: Time reproduction for 11 seconds, 36 seconds in acute manic state were shorter than in euthymic state and time reproduction in acute manic state were correlated with YMRS score. Conclusions: Time reproduction is shorter in acute manic state than in euthymic state. And the severity of manic symptom is correlated with time perception. This result is consistent with previous studies with visual stimulus and suggests that the difference between cognitive process of visual stimulus and auditory stimulus does not affect time perception. PS59 The Sex-Related Differences of EEG Coherences between Patients with Bipolar Disorder and Controls Yu-Sang Lee1, Eunsoog An1, Hyunju You1 1Yongin Mental Hospital, Republic of Korea Objectives: Sex hormones exposure during the prenatal period has an effect on cerebral lateralization. Male brains are thought to be more lateralized than female brains. Bipolar disorder was known to show abnormalities in cerebral laterality whose characteristics could be estimated by electroencephalography (EEG) coherences. We studied sex-related differences of EEG coherences between healthy controls and patients with bipolar disorder to examine the sex effects in the genesis of bipolar disorder. Methods: Participants were 25 patients with bipolar disorder (11 male, 14 female) and 46 healthy controls (23 male, 23 female). EEG was recorded in the eyes closed resting state. To examine dominant EEG coherence associated with sex differences in both groups within five frequency bands (delta, theta, alpha, beta, and gamma) across several brain regions, statistical analyses were performed using analysis of covariance. Results: Though statistically meaningful results were not found, some remarkable findings were noted. Healthy control females showed more increased interhemispheric coherences than control males in gamma frequency band. There were no differences in the intrahemispheric coherences between the healthy control males and females. In patients with bipolar disorder, female dominant pattern in interhemispheric coherences was attenuated compared with healthy control. Conclusions: Sex differences of EEG coherences, which could be a marker for cerebral laterality, were attenuated in patients with bipolar disorder compared with healthy controls. These results imply that abnormal sex hormone exposure during early development might play some role in the pathogenesis of bipolar disorder. PS60 Associations between Pro-inflammatory cytokines and grey matter/ cortical thickness in patients with bipolar disorder Ya-Mei Bai, Pei-Chi Tu, Cheng-Ta Li, Tung-Ping Su, Mu-Hong Chen Department of Psychiatry, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan