Pharmacological studies on 4 (or 5)-aminoimidazole-5 (or 4)-carboxamide (AICA) derivatives.

نویسندگان

  • K Hano
  • A Akashi
  • Y Suzuki
  • I Yamamoto
  • S Narumi
چکیده

In previous works from our laboratory (1-3) we reported that 4-diazoimidazole-5 carboxamide (diazo-ICA) and 4-(mono or di-substituted) triazenoimidazole-5-carboxamide (mono or dialkyl-TICA) showed marked inhibitory effects on the growth of tumors and bacterial cells. During examination of their toxicity in mice, behavioral sedation caused by these compounds was also observed (2). These observations led us to investigate the pharma cological properties of these compounds. The present report is on the effects of these compounds on the respiration, blood

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عنوان ژورنال:
  • Japanese journal of pharmacology

دوره 17 4  شماره 

صفحات  -

تاریخ انتشار 1967