Polygenic score analyses of schizophrenia and bipolar disorder with cardiometabolic traits
نویسندگان
چکیده
School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research of Common Diseases, Kunming Institute of Zoology and The Chinese University of Hong Kong Department of Psychiatry, University of Hong Kong, Pokfulam, Hong Kong Centre for Genomic Sciences, University of Hong Kong, Pokfulam, Hong Kong State Key Laboratory for Cognitive and Brain Sciences, University of Hong Kong, Pokfulam, Hong Kong Centre for Reproduction, Development and Growth, University of Hong Kong, Pokfulam, Hong Kong
منابع مشابه
Polygenic dissection of the bipolar phenotype
BACKGROUND Recent data provide strong support for a substantial common polygenic contribution (i.e. many alleles each of small effect) to genetic susceptibility for schizophrenia and overlapping susceptibility for bipolar disorder. AIMS To test hypotheses about the relationship between schizophrenia and psychotic types of bipolar disorder. METHOD Using a polygenic score analysis to test...
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Twin studies have demonstrated overlap between genetic contributions to posttraumatic stress disorder (PTSD) and other psychiatric disorders.1 These findings have prompted interest in examining shared genetic risk between PTSD and other psychopathology at the molecular level. With genome-wide association studies (GWAS) and collaborative consortia-based efforts, replicable risk variants have bee...
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