Inhibition of type III secretion in Salmonella enterica serovar Typhimurium by small-molecule inhibitors.
نویسندگان
چکیده
Type III secretion systems (T3SS) are conserved in many pathogenic gram-negative bacteria. Small molecules that specifically target T3SS in Yersinia and Chlamydia spp. have recently been identified. Here we show that two such compounds inhibit Salmonella T3SS-1, preventing secretion of T3SS-1 effectors, invasion of cultured epithelial cells, and enteritis in vivo.
منابع مشابه
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 51 7 شماره
صفحات -
تاریخ انتشار 2007