Fission Yeast Cell Cycle Checkpoint Mutation
نویسندگان
چکیده
We have identified a novel human gene by virtue of its ability to complement the radl-1 checkpoint mutant of Schizosaccharomyces pombe. This gene, called RACH2, rescues the temperature-sensitive lethality of a radl-1 weel-50 double mutant of S. pombe. Expression of RACH2 in S. pombe radl-1 strains partially restores UV resistance to the radl-1 mutant strain. Expression of RACH2 in a radl-1 cdc25-22 double mutant partially restores the dose-dependent delay in mitotic entry after irradiation that is lost in radl-1 checkpointdeficient mutants. Overexpression of RACH2 in human tissue culture cells induces apoptosis.
منابع مشابه
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