A single amino acid change in the murine leukemia virus capsid gene responsible for the Fv1(nr) phenotype.

نویسندگان

  • Y T Jung
  • C A Kozak
چکیده

The nr allele at the mouse Fv1 restriction locus governs resistance to B-tropic and some N-tropic murine leukemia viruses (MLVs). Sequence analysis and site-specific mutagenesis of N-tropic MLVs identified a single amino acid difference responsible for this restriction that is distinct from the site that governs N or B tropism. Viruses with other substitutions at this site were evaluated for altered replication patterns.

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عنوان ژورنال:
  • Journal of virology

دوره 74 11  شماره 

صفحات  -

تاریخ انتشار 2000