Short-term docosapentaenoic acid (22:5 n-3) supplementation increases tissue docosapentaenoic acid, DHA and EPA concentrations in rats.
نویسندگان
چکیده
The metabolic fate of dietary n-3 docosapentaenoic acid (DPA) in mammals is currently unknown. The aim of the present study was to determine the extent of conversion of dietary DPA to DHA and EPA in rats. Four groups of male weanling Sprague-Dawley rats (aged 5 weeks) were given 50 mg of DPA, EPA, DHA or oleic acid, daily for 7 d by gavage. At the end of the treatment period, the tissues were analysed for concentrations of long-chain PUFA. DPA supplementation led to significant increases in DPA concentration in all tissues, with largest increase being in adipose (5-fold) and smallest increase being in brain (1.1-fold). DPA supplementation significantly increased the concentration of DHA in liver and the concentration of EPA in liver, heart and skeletal muscle, presumably by the process of retroconversion. EPA supplementation significantly increased the concentration of EPA and DPA in liver, heart and skeletal muscle and the DHA concentration in liver. DHA supplementation elevated the DHA levels in all tissues and EPA levels in the liver. Adipose was the main tissue site for accumulation of DPA, EPA and DHA. These data suggest that dietary DPA can be converted to DHA in the liver, in a short-term study, and that in addition it is partly retroconverted to EPA in liver, adipose, heart and skeletal muscle. Future studies should examine the physiological effect of DPA in tissues such as liver and heart.
منابع مشابه
Short term DPA ( 22 : 5 n - 3 ) supplementation increases tissue DPA , DHA and EPA 1 concentration in rats
49 50 The metabolic fate of dietary n-3 docosapentaenoic acid (DPA) in mammals is currently 51 unknown. The aim of this study was to determine the extent of conversion of dietary 52 DPA to docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) in rats. Four 53 groups of male weanling Sprague Dawley rats (aged 5 weeks) were given 50 mg of 54 DPA, EPA, DHA or oleic acid, daily for 7 days by g...
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The role of the long-chain omega-3 (n-3) fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in lipid metabolism and inflammation has been extensively studied; however, little is known about the relationship between docosapentaenoic acid (DPA, 22:5 n-3) and inflammation and triglycerides (TG). We evaluated whether n-3 DPA content of red blood cells (RBC) was associated with m...
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Fatty acid composition has an important role in cellular structure and function. Inflammatory behavior of the airway epithelial cells can be changed due to the manipulation of their fatty acid content, which has a critical importance in asthma. The objective of the present study was to determine the fatty acid composition of human airway epithelial cells after co-culturing with eicosapentaenoic...
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Fish oil contains a complex mixture of omega-3 fatty acids, of which eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) are the three predominant forms. There has been a plethora of previous research on the effects and associations of fish oil supplementation with various clinical manifestations. While the majority of this work was focused on EPA and DHA as...
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ورودعنوان ژورنال:
- The British journal of nutrition
دوره 103 1 شماره
صفحات -
تاریخ انتشار 2010