Recurrent multifocal eosinophilic granuloma of the mandible and maxilla: a case report and literature review

Eosinophilic granuloma of the jaw is rare and preferably located within the posterior mandible. In this study, we report a case of multiple eosinophilic granuloma of the jaw in a 22-year-old man. This patient consulted to our hospital due to left-posterior maxilla pain that lasted for one year. X-ray and CT scan revealed an osteolytic area in the left-posterior maxilla. Then, the lesion was resected and pathologically diagnosed as an eosinophilic granuloma. Unfortunately, even though systemic radiotherapy and chemotherapy were performed, eosinophilic granuloma recurred; and new lesions developed four times at adjacent sites after one, two, five and eight years. Surgical resection, radiotherapy and chemotherapy were performed according to the patient’s status. Based on follow-ups, difficulties on eating and pronunciation caused by teeth loss were major functional problems for this patient. Considering the rarity of recurrent multifocal eosinophilic granuloma of the jaw, literatures from other studies regarding this disease were reviewed.