Ribosomal Protein S6, a target of TOR, is involved in the regulation of rRNA genes by possible epigenetic changes in Arabidopsis

نویسندگان

  • Yun-Kyoung Kim
  • Sunghan Kim
  • Yun-jeong Shin
  • Yoon-Sun Hur
  • Woo-Young Kim
  • Myung-Sok Lee
  • Choong-Ill Cheon
  • Desh Pal S. Verma
چکیده

This article contains supplemental Tables 1-2, and Figs. S1–S3. * This work was supported by a National Science Foundation (USA) grant (0726284) to DPSV, and the National Research Foundation of Korea (NRF) grants funded by the Korea government (MSIP) to Sookmyung MRC center (2011-00300074; C-I C) and to SK (NRF-2010-A0604C00031). 1 These authors contributed equally to this work. 2 To whom correspondence should be addressed: Department of Molecular Genetics and the Center for Applied Plant Sciences, Ohio State University, Columbus, Ohio 43210, USA. Tel.: 614-292-3625; Fax: 614-292-5379; E-mail: [email protected] or Department of Biological Science, Sookmyung Women’s University, Hyochangwon-gil 52, Yongsan-gu, Seoul 140-742, Korea. Tel.: +82-2-710-9396; Fax: +82-22077-7322; E-mail: [email protected].

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Arabidopsis TARGET OF RAPAMYCIN interacts with RAPTOR, which regulates the activity of S6 kinase in response to osmotic stress signals.

TARGET OF RAPAMYCIN (TOR) kinase controls many cellular functions in eukaryotic cells in response to stress and nutrient availability and was shown to be essential for embryonic development in Arabidopsis thaliana. We demonstrated that Arabidopsis RAPTOR1 (a TOR regulatory protein) interacts with the HEAT repeats of TOR and that RAPTOR1 regulates the activity of S6 kinase (S6K) in response to o...

متن کامل

The Arabidopsis TOR Kinase Specifically Regulates the Expression of Nuclear Genes Coding for Plastidic Ribosomal Proteins and the Phosphorylation of the Cytosolic Ribosomal Protein S6

Protein translation is an energy consuming process that has to be fine-tuned at both the cell and organism levels to match the availability of resources. The target of rapamycin kinase (TOR) is a key regulator of a large range of biological processes in response to environmental cues. In this study, we have investigated the effects of TOR inactivation on the expression and regulation of Arabido...

متن کامل

Gene transcriptomic profile in arabidopsis thaliana mediated by radiation-induced bystander effects

Background: The in vivo radiation-induced bystander effects (RIBE) at the developmental, genetic, and epigenetic levels have been well demonstrated using model plant Arabidopsis thaliana (A. thaliana). However, the mechanisms underlying RIBE in plants are not clear, especially lacking a comprehensive knowledge about the genes and biological pathways involved in the RIBE in plants. Materials and...

متن کامل

Effects of Major Epigenetic Factors on Systemic Lupus Erythematosus

The pathogenesis of systemic lupus erythematosus (SLE) is influenced by both genetic factors and epigenetic modifications; the latter is a result of exposure to various environmental factors. Epigenetic modifications affect gene expression and alter cellular functions without modifying the genomic sequences. CpG-DNA methylation, histone modifications, and miRNAs are the main epigenetic factors ...

متن کامل

The histone H3 lysine 56 acetylation pathway is regulated by target of rapamycin (TOR) signaling and functions directly in ribosomal RNA biogenesis

Epigenetic changes in chromatin through histone post-translational modifications are essential for altering gene transcription in response to environmental cues. How histone modifications are regulated by environmental stimuli remains poorly understood yet this process is critical for delineating how epigenetic pathways are influenced by the cellular environment. We have used the target of rapa...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2013