Design and engineering of water-soluble light-harvesting protein maquettes† †Electronic supplementary information (ESI) available: Experimental methods and supplementary Fig. S1–10. See DOI: 10.1039/c6sc02417c Click here for additional data file.
نویسندگان
چکیده
Natural selection in photosynthesis has engineered tetrapyrrole based, nanometer scale, light harvesting and energy capture in light-induced charge separation. By designing and creating nanometer scale artificial light harvesting and charge separating proteins, we have the opportunity to reengineer and overcome the limitations of natural selection to extend energy capture to new wavelengths and to tailor efficient systems that better meet human as opposed to cellular energetic needs. While tetrapyrrole cofactor incorporation in natural proteins is complex and often assisted by accessory proteins for cofactor transport and insertion, artificial protein functionalization relies on a practical understanding of the basic physical chemistry of protein and cofactors that drive nanometer scale self-assembly. Patterning and balancing of hydrophobic and hydrophilic tetrapyrrole substituents is critical to avoid natural or synthetic porphyrin and chlorin aggregation in aqueous media and speed cofactor partitioning into the non-polar core of a man-made water soluble protein designed according to elementary first principles of protein folding. This partitioning is followed by site-specific anchoring of tetrapyrroles to histidine ligands strategically placed for design control of rates and efficiencies of light energy and electron transfer while orienting at least one polar group towards the aqueous phase.
منابع مشابه
Very bright mechanoluminescence and remarkable mechanochromism using a tetraphenylethene derivative with aggregation-induced emission† †Electronic supplementary information (ESI) available: Details of the synthesis; structural information for the compound (NMR, IR, and mass spectra); Tables S1–S5; Fig. S1–S11. CCDC 1037840 and 1057432. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc00466g Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file.
PCFM Lab, GD HPPC Lab, Guangdong Eng High-performance Organic and Polymer P Laboratory of Opto-electronic Material and Chemical Engineering, Sun Yet-sen Univers [email protected]; [email protected] 20 84112222; Tel: +86 20 84112712 State Key Laboratory of Optoelectronic Mat and Engineering, Sun Yat-sen University, Gu Shenzhen China Star Optoelectronics Techn TCL Corporate Research, Guangdon...
متن کاملOptical detection of gadolinium(iii) ions via quantum dot aggregation† †Electronic supplementary information (ESI) available: Fig. S1–S7, Tables S1–S4 and Movies (CdTe680_MCS_Movie.avi and CdTe680_Gd_MCS_Movie.avi). See DOI: 10.1039/c7ra03969g Click here for additional data file. Click here for additional data file. Click here for additional data file.
متن کامل
A well-defined, versatile photoinitiator (salen)Co–CO2CH3 for visible light-initiated living/controlled radical polymerization† †Electronic supplementary information (ESI) available: Experimental details, characterization of (salen)Co–CO2CH3, Fig. S1–S20. CCDC 1031130. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc00477b Click here for additional data file. Click here for additional data file.
Yaguang Zhao,† Mengmeng Yu,† Shuailin Zhang, † Zhenqiang Wu,† Yuchu Liu,† ChiHow Peng,*‡ and Xuefeng Fu*† †Beijing National Laboratory for Molecular Sciences, State Key Lab of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China ‡Department of Chemistry and Frontier Research Center on Fundamental and Applied S...
متن کاملHigh temperature ferromagnetism in π-conjugated two-dimensional metal–organic frameworks† †Electronic supplementary information (ESI) available: (1) Computational methods; (2) electronic band structures of NiMPc MOF monolayers (Fig. S1); (3) calculation results for NiMnPc MOF monolayers with NiO4 and NiS4 moieties (Fig. S2); (4) ferromagnetic transition temperatures of 2D Heisenberg model with single-ion anisotropy (Fig. S3); (5) structure and energetics of bulk NiMnPc (Fig. S4 and S5); (6) atomistic coordinate data of NiMPc MOF monolayers. See DOI: 10.1039/c6sc05080h Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file.
Research Laboratory of Electronics, M Cambridge, Massachusetts 02139, USA Department of Chemistry, Massachusett Massachusetts 02139, USA. E-mail: mdinca@ Department of Nuclear Science and Enginee Engineering, Massachusetts Institute of Tech USA. E-mail: [email protected] Department of Physics, Massachusetts Massachusetts 02139, USA † Electronic supplementary information methods; (2) electronic band ...
متن کاملSystematic re-evaluation of the bis(2-hydroxyethyl)disulfide (HEDS) assay reveals an alternative mechanism and activity of glutaredoxins† †Electronic supplementary information (ESI) available: Alternative evaluation of the HEDS assay with ScGrx7 (Fig. S1), HEDS and GSSEtOH assay with PfGrx (Fig. S2), enzyme parameters for the GSSEtOH assay with ScGrx7 (Table S1) and calculations of estimated reaction velocities and substrate concentrations (Tables S2–4). See DOI: 10.1039/c5sc01051a Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file.
متن کامل