c-Maf plays a crucial role for the definitive erythropoiesis that accompanies erythroblastic island formation in the fetal liver Short title for the running head: c-Maf IS CRUCIAL FOR ERYTHROPOIESIS IN FETAL LIVER
نویسندگان
چکیده
Department of Anatomy and Embryology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan; Laboratory of Stem cell Research and Application, University of Science Ho Chi Minh city, Vietnam; Department of Molecular Biological Oncology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan; Department of Clinical and Experimental Hematology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan Blood First Edition Paper, prepublished online May 31, 2011; DOI 10.1182/blood-2010-08-300400
منابع مشابه
c-Maf rules the island.
The erythroblastic island was ultrastructurally identified as a common organizational unit of bone marrow more than 50 years ago.2 Erythroblastic islands are composed of erythroblasts, at various stages of maturation, and a central macrophage. The central macrophage supports erythroid cell survival and proliferation through intercellular signaling, and facilitates enucleation.3 Along this line,...
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Tropomodulin (Tmod) is a protein that binds and caps the pointed ends of actin filaments in erythroid and nonerythoid cell types. Targeted deletion of mouse tropomodulin3 (Tmod3) leads to embryonic lethality at E14.5-E18.5, with anemia due to defects in definitive erythropoiesis in the fetal liver. Erythroid burst-forming unit and colony-forming unit numbers are greatly reduced, indicating defe...
متن کاملGeneration of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor
Erythropoietin (EPO) is the principal growth factor regulating the production of circulating erythrocytes. We introduced null mutations into both Epo and the EPO receptor (EpoR) gene. Both heterozygotes appeared normal. Homozygous animals exhibited reduced primitive erythropoiesis and died around embryonic day 13, owing to failure of definitive fetal liver erythropoiesis. Both types of mutation...
متن کاملMEK kinase 1 activity is required for definitive erythropoiesis in the mouse fetal liver.
Mitogen-activated protein kinase/extracellular signal to regulated kinase (MEK) kinase 1 (MEKK1) is a c-Jun N-terminal kinase (JNK) activating kinase known to be implicated in proinflammatory responses and cell motility. Using mice deficient for MEKK1 kinase activity (Mekk1(DeltaKD)) we show a role for MEKK1 in definitive mouse erythropoiesis. Although Mekk1(DeltaKD) mice are alive and fertile ...
متن کاملAbsence of erythroblast macrophage protein (Emp) leads to failure of erythroblast nuclear extrusion.
In mammals, the functional unit for definitive erythropoiesis is the erythroblastic island, a multicellular structure composed of a central macrophage surrounded by developing erythroblasts. Erythroblast-macrophage interactions play a central role in the terminal maturation of erythroblasts, including enucleation. One possible mediator of this cell-cell interaction is the protein Emp (erythrobl...
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