Penicillin-bin Ding Proteins in Bacillus Subtilis the Effects on Penicillin-binding Proteins and the Antibacterial Activities of 3-lactams
نویسنده
چکیده
Several,3-lactams were investigated on the affinity for the penicillin-binding proteins (PBPss) and the antibacterial activity in Bacillus subtilis. The 19-lactams uch as ampicillin, PS-5, methicillin and SCE-963, which had high affinities for PBP-2 showed strong antibacterial activities and the 3-lactams such as cephamycin C, Y-G19Z-GG and Y-G19Z-G, which had high affinities for PBP-1 but low affinities for PBP-2, showed weak antibacterial activities. Clavulanic acid and nocardicin A, which had almost no affinities for all the PBPs detected, showed very low antibacterial activities. These results suggest that PBP-2 in Bacillus subtilis is the lethal target of these,3-lactam antibiotics.
منابع مشابه
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