Current State of Alzheimers Disease Research Therapeutics

The most valuable biomarkers of Alzheimer\'s disease: a review article

Alzheimer’s disease (AD) is the most popular type of dementia in elderly and is described by a progressive loss of cognitive capacity and severe neurodegeneration which typically begins with memory deficits. The major biomarkers of AD include total tau, phosphorylated-tau and 42 amino acid isoform of amyloid beta that reflect neurodegeneration and indicate the pathophysiological processes in AD...

Roles of Stem Cells in the Treatment of Alzheimer’s Disease

Introduction: Alzheimer disease (AD), known to be a leading cause of dementia that causes heavy social and financial burdens worldwide, characterized by progressive loss of neurons and synaptic connectivity after depositions of amyloid-β (Aβ) protein.AD manifests as an impaired ability to comprehend or use words, poor coordination and gait, and impaired executive functions in the realms of plan...

Low Levels of Triiodothyronine in Patients with Alzheimer’s Disease

CLK / DYRK kinases inhibitor Leucettine L 41 induces mTOR - dependent autophagy . Implication for Alzheimers ’ disease

C.N.R.S., USR3151, ‘Protein Phosphorylation & Human Disease’, Station Biologique, place Georges Teissier, CS 90074, 29688 Roscoff Cedex, FRANCE (XF, ED). Inserm/UPS UMR 1048, ‘Production et fonctions plaquettaires: signalisation et phosphoinositides’ group, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), 1, Avenue Jean Poulhès, BP 84225, 31432 Toulouse cedex 4, FRANCE (GC, BP). ...

A Prospective Study to Assess Vancomycin Serum Concentrations in Pediatric Patients with Current Dosing Guidelines

Concerns about increasing bacterial resistance to vancomycin, have caused the adult treatment guidelines to recommend higher trough concentrations based on the type and location of infectious disease. Although these recommendations are not specific to children, the values can be extrapolated. This prospective study was designed to evaluate efficacy of current vancomycin dosing recommendations t...