Defining the Role of Hepatic Arterial Infusion Chemotherapy in Metastatic Colorectal Cancer
نویسنده
چکیده
Drs. Whisenant and Venook have provided us with a summary of the role of hepatic arterial infusion (HAI) chemotherapy for patients with metastatic colorectal cancer. In their abstract they state that there is confusion about whether HAI for unresectable liver metastases is useful, because European studies have been negative; they go on to say that the work in adjuvant therapy has mixed results. I would like to offer some different interpretations.
منابع مشابه
Defining the role of hepatic arterial infusion chemotherapy in metastatic colorectal cancer.
The use of hepatic arterial infusion (HAI) chemotherapy in patients with liver-only colorectal metastases is based on the pharmacologic principle that the regional administration of some drugs can lead to higher drug concentrations at the site of the metastases and avoid systemic toxicity. Early randomized trials resulted in high response rates but did not lead to a survival advantage with HAI....
متن کاملSurgical and ablative modalities for the treatment of colorectal cancer metastatic to the liver.
Colorectal cancer is the second leading cause of mortality from cancer in the United States. Death from colorectal cancer usually results from metastatic disease to the liver. Complete surgical resection is the only potentially curative treatment option for metastatic colorectal cancer to the liver, with a five-year survival rate of approximately 30%-40%. The addition of adjuvant systemic or he...
متن کاملIntra arterial hepatic chemotherapy for unresectable colorectal metastases: (review).
BACKGROUND Hepatic arterial infusion (HAI) chemotherapy is based on the idea that liver metastases are perfused almost exclusively by the hepatic artery. This approach has been extensively investigated in 1970s and 1980s. Currently, there is a worldwide growing interest in intraarterial therapeutic approaches for hepatic metastases. The principal aim of this review was to define current role of...
متن کاملIntrahepatic Chemotherapy 2 for Metastatic Colorectal Cancer
Colorectal cancer (CRC) is the fourth most common malignancy in the United States (1). Approximately 130,000 new patients will be diagnosed with this cancer in 1999. It is the second leading cause of cancer death, with 55,000 patients expected to die of it. Most patients die of metastatic disease. The vast majority of them have liver as the dominant site of metastases (2). Approximately 30% of ...
متن کاملHepatic arterial infusion of chemotherapy for hepatic metastases from colorectal cancer.
BACKGROUND Sixty percent of colon cancer patients develop liver metastasis. Only 25% of those have potentially resectable hepatic metastases, and approximately 58% of those patients relapse. METHODS We review the indications and the technical aspects of hepatic artery infusion (HAI) of chemotherapy, as well as the efficacy, morbidity, and outcomes. RESULTS HAI of chemotherapy has been used ...
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