Maternal hypoxia alters matrix metalloproteinase expression patterns and causes cardiac 1 remodeling in fetal and neonatal rats
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چکیده
Running title: Fetal hypoxia and heart remodeling 12 13 14 15 Corresponding author: 16 Lubo Zhang, PhD 17 Center for Perinatal Biology 18 Division of Pharmacology 19 Department of Basic Sciences 20 Loma Linda University School of Medicine 21 Loma Linda, CA 92350 22 Tel: 909-558-4325 23 Fax: 909-558-4029 24 Email: [email protected] 25 26 27 Articles in PresS. Am J Physiol Heart Circ Physiol (August 19, 2011). doi:10.1152/ajpheart.00356.2011
منابع مشابه
Maternal hypoxia alters matrix metalloproteinase expression patterns and causes cardiac remodeling in fetal and neonatal rats.
Fetal hypoxia leads to progressive cardiac remodeling in rat offspring. The present study tested the hypothesis that maternal hypoxia results in reprogramming of matrix metalloproteinase (MMP) expression patterns and fibrillar collagen matrix in the developing heart. Pregnant rats were treated with normoxia or hypoxia (10.5% O(2)) from day 15 to 21 of gestation. Hearts were isolated from 21-day...
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