Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.

نویسندگان

  • Joan Malmstrøm
  • Carsten Christophersen
  • Alejandro F Barrero
  • J Enrique Oltra
  • José Justicia
  • Antonio Rosales
چکیده

From a marine-derived strain of the fungus Emericella variecolor, varitriol (1), varioxirane (2), dihydroterrein (3), and varixanthone (4), besides the known mold metabolites ergosterol, terrein, shamixanthone, and tajixanthone hydrate, were identified. The chemical structures of 1-4 were established by means of spectroscopic techniques and some chemical transformations. In the NCI's 60-cell panel, varitriol (1) displayed increased potency toward selected renal, CNS, and breast cancer cell lines. Varixanthone (4) showed antimicrobial activity.

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عنوان ژورنال:
  • Journal of natural products

دوره 65 3  شماره 

صفحات  -

تاریخ انتشار 2002