Hypoxia-inducible factor 2a regulates key neutrophil functions in humans, mice, and zebrafish
نویسندگان
چکیده
Hypoxia-inducible factor 2a regulates key neutrophil functions in humans, mice, and zebrafish A. A. Roger Thompson, Philip M. Elks, Helen M. Marriott, Suttida Eamsamarng, Kathryn R. Higgins, Amy Lewis, Lynne Williams, Selina Parmar, Gary Shaw, Emmet E. McGrath, Federico Formenti, Fredericus J. Van Eeden, Vuokko L. Kinnula, Christopher W. Pugh, Ian Sabroe, David H. Dockrell, Edwin R. Chilvers, Peter A. Robbins, Melanie J. Percy, M. Celeste Simon, Randall S. Johnson, Stephen A. Renshaw, Moira K. B. Whyte, and Sarah R. Walmsley
منابع مشابه
Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.
Neutrophil lifespan and function are regulated by hypoxia via components of the hypoxia inducible factor (HIF)/von Hippel Lindau/hydroxylase pathway, including specific roles for HIF-1α and prolyl hydroxylase-3. HIF-2α has both distinct and overlapping biological roles with HIF-1α and has not previously been studied in the context of neutrophil biology. We investigated the role of HIF-2α in reg...
متن کاملAMP-Activated Protein Kinase α2 in Neutrophils Regulates Vascular Repair via Hypoxia-Inducible Factor-1α and a Network of Proteins Affecting Metabolism and Apoptosis
RATIONALE The AMP-activated protein kinase (AMPK) is stimulated by hypoxia, and although the AMPKα1 catalytic subunit has been implicated in angiogenesis, little is known about the role played by the AMPKα2 subunit in vascular repair. OBJECTIVE To determine the role of the AMPKα2 subunit in vascular repair. METHODS AND RESULTS Recovery of blood flow after femoral artery ligation was impaire...
متن کاملNeutrophil survival in the death zone.
In this issue of Blood, Thompson et al reveal a key role for hypoxia-inducible factor (HIF)-2a in the adaptation of neutrophils to hypoxia. Tissue hypoxia is a common feature of trauma and inflammation. Infiltrating neutrophils must adapt to this low-oxygen environment to satisfy the metabolic and functional demands of an immune response.
متن کاملNovel Functions of ErbB4 and NRG-1 in Development and Cancer
Cells communicate, or signal, with each other constantly to ensure proper functioning of tissues and organs. Cell signaling is often performed by interplay of receptors and ligands that bind these receptors. ErbB receptors (epidermal growth factor receptors, EGFR, HER) bind extracellular growth factors and transduce these signals inside of cells. ErbB dysfunction promotes carcinogenesis, and al...
متن کاملE2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1.
The E2F family of transcription factors plays an important role in controlling cell-cycle progression. While this is their best-known function, we report here novel functions for the newest members of the E2F family, E2F7 and E2F8 (E2F7/8). We show that simultaneous deletion of E2F7/8 in zebrafish and mice leads to severe vascular defects during embryonic development. Using a panel of transgeni...
متن کامل