A NEW BIOACTIVE SCHIFF BASE LIGANDS DERIVED FROM AZOSULFAPYRIMIDINE AND THEIR Fe(III), Co(II) AND Ni(II) COMPLEXES: SYNTHESIS, THERMAL, MAGNETIC AND SPECTROSCOPIC CHARACTERIZATION, 3D MODELING AND BIOLOGICAL STUDIES

New series of Fe (III), Co (II) and Ni (II) complexes of Schiff base ligands HL and H2L derived from azosulfapyrimidine were synthesized and characterized by elemental, conductance measurements, IR, electronic absorption, EPR spectra and magnetic measurements. 3D modeling of the ligand and its metal complex indicated that the electron density on the azomethine groups are much higher than the azo group therefore coordination would take place via the azomethine group and the azo group does not participate in complex formation. The complexes exhibited different geometrical arrangements. The variation in the geometrical arrangements depends on the nature of both the metal ions and the Schiff base ligands. The thermo kinetic parameters are calculated indicates the activated complex is more ordered than the reactants and / or thermal decomposition reaction is slower than normal. The biological activities of the ligands and complexes have been screened in vitro against some bacteria and fungi to study their capacity to inhibit their growth and to study the toxicity of the compounds.