From genesis to genes.

I-38: Search for Genetic Causes of Male Infertility

Background: We are convinced that better infertility treatment will only be achieved with a better under understanding of the molecular mechanisms specific to each patient. To that effect we want to indentify genes involved in male infertility. Materials and Methods: We screened cohorts of infertile men to identify the cause of their infertility. Results: Our team has identified and caracterize...

Identification of a Novel Intragenic Deletion of the PHKD1 Gene in a Patient with Autosomal Recessive Polycystic Kidney Disease

Background Autosomal recessive polycystic kidney disease (ARPKD) is caused by mutations in the PKHD1gene. In the present study, we describe a severe case of ARPKD carrying a point mutation and a novel four-exon deletion of PKHD1 gene. Materials and Methods The PKHD1, PKD1 and PKD2 ...

DIFFERENT TYPES OF ROCKBALLS AND THEIR GENESIS FROM THE KARAJ FORMATION (MIDDLE EOCENE) IN CENTRAL ALBORZ, OF NORTHERN IRAN

The cytochrome P450 genesis locus: the origin and evolution of animal cytochrome P450s.

The neighbourhoods of cytochrome P450 (CYP) genes in deuterostome genomes, as well as those of the cnidarians Nematostella vectensis and Acropora digitifera and the placozoan Trichoplax adhaerens were examined to find clues concerning the evolution of CYP genes in animals. CYP genes created by the 2R whole genome duplications in chordates have been identified. Both microsynteny and macrosynteny...

Genesis of the Kishan Pb-Zn mineralization, western Iran based on mineralogy, fluid inclusion and sulfur isotope evidences

Kishan lead-zinc deposit is one of the Malayer-Esfahan metallogenic belt deposits, located NW Arak, Markazi Province. The fluid inclusion microthermometry of the primary liquid-vapor bearing fluid inclusions trapped in the cogenetic quartz veins exhibited a homogenization temperature ranges from 140 and 272 °C (average 208.47 °C from 68 fluid inclusions), corresponding with the salinity of 10 t...

The synthetic multivulval genes of C. elegans: functional redundancy, Ras-antagonism, and cell fate determination.

Development of the C. elegans vulva requires coordination between a strikingly complex set of molecular regulators and pathways. In particular, the correct specification of vulval cell-fates requires both the activation of RTK/Ras/Map kinase members as well as negative regulation by a set of genes known as the SynMuvs. SynMuvs comprise two functionally redundant sets of genes that appear to ant...