Development of Presynaptic Calcium Dynamics and Short-term Plasticity in the Sc-ca1 Synapse By
نویسندگان
چکیده
OF DISSERTATION Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Biomedical Science The University of New Mexico Albuquerque, New Mexico
منابع مشابه
Short-term plasticity constrains spatial organization of a hippocampal presynaptic terminal.
Although the CA3-CA1 synapse is critically important for learning and memory, experimental limitations have to date prevented direct determination of the structural features that determine the response plasticity. Specifically, the local calcium influx responsible for vesicular release and short-term synaptic facilitation strongly depends on the distance between the voltage-dependent calcium ch...
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Recent studies show extensive presence of Endoplasmic Reticulum (ER) in the presynaptic terminals of CA3-CA1 synapses in the hippocampus. Separately, it has been suggested in that calcium release from intracellular stores plays an important role in various forms of plasticity, however the exact role of presynaptic calcium stores has not been quantified. One of the reasons being the technical di...
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UNLABELLED Post-tetanic potentiation (PTP) is a widespread form of short-term synaptic plasticity in which a period of elevated presynaptic activation leads to synaptic enhancement that lasts tens of seconds to minutes. A leading hypothesis for the mechanism of PTP is that tetanic stimulation elevates presynaptic calcium that in turn activates calcium-dependent protein kinase C (PKC) isoforms t...
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Synapses display remarkable alterations in strength during repetitive use. Different types of synapses exhibit distinctive synaptic plasticity, but the factors giving rise to such diversity are not fully understood. To provide the experimental basis for a general model of short-term plasticity, we studied three synapses in rat brain slices at 34 degrees C: the climbing fiber to Purkinje cell sy...
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We develop a spatially explicit biophysical model of the hippocampal CA3-CA1 presynaptic bouton to study local calcium dynamics leading to vesicle fusion. A kinetic model with two calcium sensors is formulated specifically for the CA3-CA1 synapse. The model includes a sensor for fast synchronous release that lasts a few tens of milliseconds and a sensor for slow asynchronous release that lasts ...
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