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Introduction A number of theories have been proposed that relate the differentiation pathway of mesenchymal stem cells (MSCs) to their biomechanical environment during healing. In addition, the organisation of the ECM determines the mechanical fitness of any repair tissue. A key structural component in most soft tissues is collagen. Our hypothesis is that both cell phenotype and the collagen organisation during skeletal repair are in part regulated by mechanical loading. This hypothesis will be investigated using theoretical mechanobiology models.
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Introduction: Hyaluronic acid (HA) is an anionic biopolymer composed of alternating disaccharide units of D-glucuronic acid and Nacetyl-D-glucosamine with (14)interglycosidic linkage [1]. It is the only nonsulfated glycosaminoglycan (GAG) that is abundant in the synovial fluid and extracellular matrix (ECM) [1-2]. The over all goal of this study is to fabricate and characterize nanospheres ba...
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