Persistence of toluene diisocyanate-induced asthma despite negligible workplace exposures.

Frequency and trends of occupational asthma due to toluene diisocyanate: a critical review.

In recent years, occupational asthma has become the most frequent occupational lung disease in many countries. Reports and statements on the frequency of occupational asthma due to isocyanates are quite contradictory. In order to clarify the issue, a critical review of the medical literature of the past half century worldwide has been performed, with special emphasis on toluene diisocyanate (TD...

Occupational asthma, lung function decrement, and toluene diisocyanate (TDI) exposure: a critical review of exposure-response relationships.

An extensive amount of clinical/epidemiological literature exists regarding the effects of toluene diisocyanate (TDI) exposure on respiratory health. This review presents an evaluation and synthesis of that literature with an emphasis on assessing exposure-response relationships in the workplace. The key respiratory disorders examined are bronchial asthma and an accelerated decline in lung func...

Diisocyanate-Induced Asthma Inflammation in a Murine Model of Toluene Factor to Airway Hyperresponsiveness and Contribution of Vascular Endothelial Growth

Bronchoalveolar lavage in allergic asthma.

induced by toluene diisocyanate. Am Rev Respir Dis, 1987, 136, 36-42. 8. Boschcuo P, Fabbri LM, Zocca E. Milani OF, Pivirotto P, Dal Vecchio A, Plebani M, Mapp CB. Prednisone inhibits late asthmatic reactions and airway infli!Jllmation induced by toluene diisocyanate in seruitiz.ed subjects. J Allergy Clin lmmunol, 1987, 80, 261267. 9. Fabbri LM, Di Giaromo R. Dal Vecchio L, Zocca E, De Marzo N...

Immune mediators in a murine model for occupational asthma: studies with toluene diisocyanate.

Isocyanate-induced asthma, which is the most common type of occupational asthma, has been difficult to diagnose and control, in part, because the biological mechanisms responsible for the disease and the determinants of exposure are not fully defined. To help address these issues, we recently established a murine model of toluene diisocyanate (TDI) asthma using inhalation exposure paradigms con...